Ann Haberman 26th ACMM “2020 Visions in Microscopy”

Ann Haberman

Ann Haberman is an Associate Professor in the departments of Immunobiology and Laboratory Medicine at Yale University. She holds a PhD in Immunology from the University of Pennsylvania and a BA in Biochemistry from the University of California Berkeley. In addition to pursuing basic research in Immunology, she oversees two core facilities at Yale – one that offers high-parameter flow cytometry and another that supports and performs multiphoton laser scanning microscopy in live anesthetized mice. With intravital multiphoton LSM, researchers can observe and track the movement of fluorescently labeled structures and cells in vivo as they interact and respond to their environment. In this way, the movement of cells can be examined within the 3D imaged volume over a prolonged period of time under physiologic conditions. This approach has been used by Yale researchers to analyze the location and timing of cellular interactions, cell division, cell death and signaling as well as larger-scale shifts in tissue architecture in many tissue types. She collaborates closely with users to guide their experimental design and image analysis, a critical component of successful hypothesis testing in vivo. Her personal research focuses on the formation and function of an inducible lymphoid tissue structure called germinal centers, in particular the factors influencing cell fate during B lymphocyte clonal self-renewal and effector differentiation during the early stages of an immune response and within these structures.